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Klow

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BPC-157 / TB-500 / GHK-Cu (GLOW)GLOW + KPVKLOW BlendQuad Peptide Blend

A potent blend of four peptides—BPC-157, TB-500, GHK-Cu, and KPV—designed to support angiogenesis, cellular migration, extracellular matrix remodeling, and anti-inflammatory pathways in preclinical research. Premium Research Peptide.

All products currently listed on this site are for research purposes only.

Original price was: $109.99.Current price is: $98.99.

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How Klow Works

The Science, Simplified

Quad-Pathway Regeneration

KLOW builds upon the GLOW formula by adding KPV, a potent anti-inflammatory tripeptide derived from α-MSH. It targets four distinct pathways: VEGF (angiogenesis), Actin (migration), Collagen (structure), and NF-κB (inflammation). Key insight: By targeting four pathways simultaneously, research suggests a synergistic effect across tissue-repair and inflammatory signaling pathways in the repair cascade.

NF-κB Inhibition via KPV

KPV (Lys-Pro-Val) inhibits the activation of NF-κB, a master regulator of the inflammatory response, at nanomolar concentrations.

Key insight: Unlike many anti-inflammatories, KPV utilizes PepT1-mediated cellular uptake, allowing it to modulate intracellular inflammatory signals up to 85% more effectively in models of intestinal and dermal distress.

Enhanced Epithelial Repair

The combination of TB-500 and BPC-157 facilitates rapid re-epithelialization by mobilizing repair cells and promoting granulation tissue formation.

Key insight: Preclinical data shows a 61% increase in the speed of wound closure and epithelial restoration when these pathways are activated in unison compared to saline controls.

Genomic Collagen Modulation

GHK-Cu modulates over 4,000 human genes, specifically those responsible for shifting the extracellular matrix from a fibrotic (scar) state to a remodeling state.

Research indicates a 70% increase in collagen synthesis, providing the structural framework necessary for functional, high-integrity tissue rebuilding.

Research Handling Notes

What research literature describes

The KLOW blend is characterized in research, as it combines naturally occurring peptide fragments that work with the body's existing repair mechanisms.

🧿 Reagent Handling Guidance

10%

Store Lyophilized at -20°C

lab use

0%

Reconstitute for Lab Use

lab use

0%

Protect From Light

lab use

Safety Advantage

Intracellular Specificity

The addition of KPV enhances the safety profile by addressing inflammation at the source without the systemic activity of corticosteroids.
  • Low Immunogenicity: Because KPV is a fragment of a naturally occurring human hormone (α-MSH), it is highly biocompatible.
  • Non-Hormonal: Despite its origin, KPV does not trigger pigment changes or adrenal activity.
  • BPC-157 Safety: Multiple animal studies confirm no LD50 (lethal dose), even at extremely high concentrations.

Compound Information

Technical specifications for each component

🔬 Molecular Profile

What Is In KLOW?

BPC-157

15 amino acids, 1,419 Da

TB-500

43 amino acids, 4,963 Da

GHK-Cu

3 amino acids + Cu²⁺, 403 Da

KPV

3 amino acids (Lys-Pro-Val), 342 Da

Total peptides

4 distinct compounds

Mechanisms

Complementary pathways

PubChem Databases

🧊 Storage Requirements

Stability Information

BPC-157 and TB-500 are in preclinical research stages, GHK-Cu is studied in dermatological and biochemical research settings, while KPV remains a research compound under ongoing study.

Lyophilized (powder)

-20°C long-term

Reconstituted

2-8°C

use within 7 days

Light protection

Store away from light

📋 Research Status

Where Each Stands

BPC-157 and TB-500 are in preclinical research stages, GHK-Cu is studied in dermatological and biochemical research settings, while KPV remains a research compound under ongoing study.

BPC-157 studies

200+ publications

TB-500 studies

170+ publications

GHK-Cu studies

130+ publications

KPV studies

100+ publications

Combination studies

Emerging research

PubMed Search

Frequently Asked Questions

Common questions about Klow

KLOW is a "Quad Peptide Blend." It includes everything in the GLOW formula (BPC-157, TB-500, GHK-Cu) but adds KPV. KPV provides an extra layer of anti-inflammatory control, making KLOW a more comprehensive option for researching injuries where chronic inflammation is a factor.
KPV (Lys-Pro-Val) is a tripeptide studied for its potent anti-inflammatory properties. In the KLOW blend, it acts to inhibit the NF-κB pathway, helping to lower pro-inflammatory cytokines and create an environment that is more conducive to the combined actions of the other three peptides.
KLOW is primarily used in preclinical models for complex tissue repair, including intestinal inflammation (IBD), tissue-repair processes, and musculoskeletal models where localized inflammation is a variable of interest.
No. KLOW is strictly an investigational research compound. It is not FDA-approved for the treatment of any disease. Its components BPC-157 and TB-500 are specifically banned by the World Anti-Doping Agency (WADA) for use in professional sports.
The lyophilized (freeze-dried) powder should be stored in a freezer at -20°C for long-term stability. Once reconstituted with bacteriostatic water, the solution must be kept refrigerated at 2-8°C and used within 7 to 10 days to maintain maximum peptide integrity.

Sources & References

Peer-reviewed research

Gastroenterology

PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation

2008

Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al.

View Source

British Journal of Pharmacology

α-MSH Related Peptides: A New Class of Anti-Inflammatory and Immunomodulating Drugs

2007

Luger TA, Brzoska T, Scholzen TE, et al.

View Source

Molecular Pharmaceutics

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

2017

Xiao B, Xu Z, Viennois E, et al.

View Source

International Journal of Molecular Sciences

Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

2018

Pickart L, Margolina A

View Source

Nature Scientific Reports

Thymosin Beta 4 and Cardiac Repair

2017

Chi NC et al.

View Source

Current Pharmaceutical Design

BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Repair, Lessons from Tendon, Ligament, Muscle and Bone Repair

2018

Seiwerth S et al.

View Source

Multiple Sources

Combined Peptide Research Literature

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Multiple Sources

Individual Peptide Research Literature

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All research data and findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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